safir

Initial Characterization of the SAFIR Prototype PET-MR Scanner

The SAFIR collaboration is currently developing a high-rate positron emission tomography (PET) insert to study fast kinetic processes in small animals. Our insert is designed for simultaneous image acquisition with a preclinical 7 T magnetic resonance (MR) imaging device. In contrast to existing preclinical PET scanners and inserts, our hardware is optimized for high-rate measurements with source activities up to 500 MBq. As a first step, the SAFIR Prototype insert was constructed. This already incorporates the final components, but has a reduced axial field-of-view (35.6 mm). We use lutetiumyttrium oxyorthosilicate crystals (2.12 mm × 2.12 mm × 13 mm) one-to-one coupled to silicon photomultipliers. All analog signals are digitized within the insert. We use 49 MR-compatible dc– dc converters in the insert to provide the power to all readout of the static B0 field in the MR scanner was observed. During full operation, we saw a minor reduction in the signal-to-noise ratio of the MR data of 4.9%. With a low activity point source (22Na 0.65 MBq) we obtained a coincidence energy resolution of 13.8% full width at half maximum (FWHM) and a coincidence timing resolution of 194 ps (FWHM). First PET/MR rat brain and high-rate mouse cardiac images (84.9 MBq) are shown in this article.

Researchers

Christian Ritzer
Robert Becker
Alfred Buck
Volker Commichau
Jan Debus
Lubomir Djambazov
Afroditi Eleftheriou
Jannis Fischer
Peter Fischer
Mikiko Ito
Parisa Khateri
Werner Lustermann
Michael Ritzert
Ulf Röser
Markus Rudin
Ilaria Sacco
Charalampos Tsoumpas
Geoffrey Warnock
Matthias Wyss
PD Dr. Dr. Matthias T Wyss
Agnieszka Zagozdzinska-Bochenek
Prof. Dr. Bruno Weber
Prof. Dr. Bruno Weber
Günther Dissertori

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