Group Leader

Prof. Dr. Bruno Weber

Room

Y17 J03

Phone+41 44 635 60 85

Mailbweber@pharma.uzh.ch

About

We ask very simple questions about the most complex system on the planet. Fascinated by these simple questions and how challenging it is to answer them, my goal is to bring together the very best people with the very best tools. Apart from running the lab for Neuroenergetics and Experimental Imaging, I act as the Director of the Institute of Pharmacology and Toxicology.

Prof. Dr. Bruno Weber

Related publications

76

Transcranial Cortex-Wide Imaging of Murine Ischemic Perfusion With Large-Field Multifocal Illumination Microscopy

Chen Z – Stroke

Mouse 400 Hz Window

Pia-FLOW: Deciphering hemodynamic maps of the pial vascular connectome and its response to arterial occlusion

Glueck C – PNAS

Astrocytes adopt a progenitor-like migratory strategy for regeneration in adult brain

Herwerth M, Wyss MT – bioRXiv

The Astrocyte: Metabolic Hub of the Brain

Barros LF – Cold Spring Harbor Perspectives in Biology

Leptomeningeal collaterals regulate reperfusion in ischemic stroke

Binder NF, El Amki M – Neuron

Oligodendrocyte–axon metabolic coupling is mediated by extracellular K+ and maintains axonal health

Looser ZJ – Nature Neuroscience

Sensitive multicolor indicators for monitoring norepinephrine in vivo

Kagiampaki Z – Nature Communications

Transcranial cortex-wide imaging of murine ischemic perfusion with large-field multifocal illumination fluorescence microscopy

Chen Z – Biorxiv

Deep optoacoustic localization microangiography of ischemic stroke in mice

Deán-Ben XL – Nature Communications

Ultrasound trapping and navigation of microrobots in the mouse brain vasculature

Del Campo Fonseca A – Nature Communications

SAFIR-I: first NEMA NU 4-2008-based performance characterization

Bebié P – European Journal of Nuclear Medicine and Molecular Imaging

Simultaneous dynamic glucose-enhanced (DGE) MRI and fiber photometry measurements of glucose in the healthy mouse brain

Eleftheriou A – NeuroImage

Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation

Todorova V – Molecular Neurodegeneration

Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure

Berthiaume AA – Nature Communications

A genetically encoded sensor for in vivo imaging of orexin neuropeptides

Duffet L – Nature Methods

Three-dimensional wide-field fluorescence microscopy for transcranial mapping of cortical microcirculation

Zhou Q – Nature Communications

Altered hemodynamics and vascular reactivity in a mouse model with severe pericyte deficiency

Stobart J – Journal of Cerebral Blood Flow and Metabolism

oxygen-phosphorescence

Measurement of cerebral oxygen pressure in living mice by two-photon phosphorescence lifetime microscopy

Erlebach E – STAR Protocols

Vascular Response to Spreading Depolarization Predicts Stroke Outcome

Binder NF – Stroke

Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning

Hoesli L – Cell Reports

MAX_21.1.21_hippo_40x_z-1-1_2

Direct vascular contact is a hallmark of cerebral astrocytes

Hoesli L – Cell Reports

Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence

Zhang K – Nature Neuroscience

Diversity of neurovascular coupling dynamics along vascular arbors in layer II/III somatosensory cortex.

Rungta RL – Communications Biology

astrocyte-calcium

Distinct signatures of calcium activity in brain mural cells

Glueck C – eLife

The severity of microstrokes depends on local vascular topology and baseline perfusion

Schmid F – eLife

Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans

Passini FS – Nature Biomedical Engineering

DeepVesselNet: Vessel Segmentation, Centerline Prediction, and Bifurcation Detection in 3-D Angiographic Volumes

Tetteh G – Frontiers in Neuroscience

Predicting Vessel Diameter Changes to Up-Regulate Biphasic Blood Flow During Activation in Realistic Microvascular Networks

Epp R – Frontiers in Physiology

A complete pupillometry toolbox for real-time monitoring of locus coeruleus activity in rodents

Privitera M – Nature Protocols

A Bright and Colorful Future for G-Protein Coupled Receptor Sensors

Ravotto L – Frontiers in Cellular Neuroscience

Structural basis of astrocytic Ca2+ signals at tripartite synapses

Arizono M – Nature Communications

Arousal-induced cortical activity triggers lactate release from astrocytes

Zuend M – Nature Metabolism

Initial Characterization of the SAFIR Prototype PET-MR Scanner

Ritzer C – IEEE transactions on radiation and plasma medical sciences

neutrophils-stroke

Neutrophils Obstructing Brain Capillaries Are a Major Cause of No-Reflow in Ischemic Stroke

El Amki M, Glueck C – Cell Reports

Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation

Zerbi V – Neuron

In vivo imaging with a water immersion objective affects brain temperature, blood flow and oxygenation

Roche M – eLife

Red blood cells stabilize flow in brain microvascular networks

Schmid F – PLoS Computational Biology

oxygen-phosphorescence

Oxyphor 2P: A High-Performance Probe for Deep- Tissue Longitudinal Oxygen Imaging

Esipova TV – Cell Metabolism

highres_RCaMPinsulin_GTP12_003_scalebar

Non-Canonical Control of Neuronal Energy Status by the Na+ Pump

Baeza-Lehnert F – Cell Metabolism

The Relation between Capillary Transit Times and Hemoglobin Saturation Heterogeneity. Part 2: Capillary Networks

Lücker A – Frontiers in Physiology

astrocyte-calcium

Cortical Circuit Activity Evokes Rapid Astrocyte Calcium Signals on a Similar Timescale to Neurons

Stobart J – Neuron

The Relation between Capillary Transit Times and Hemoglobin Saturation Heterogeneity. Part 1: Theoretical Models

Lücker A – Frontiers in Physiology

Intravitreal AAV-Delivery of Genetically Encoded Sensors Enabling Simultaneous Two-Photon Imaging and Electrophysiology of Optic Nerve Axons

Looser ZJ – Frontiers in Cellular Neuroscience

DCC Is Required for the Development of Nociceptive Topognosis in Mice and Humans

da Silva RV – Cell Reports

Long-term in vivo calcium imaging of astrocytes reveals distinct cellular compartment responses to sensory stimulation

Stobart J – Cerebral Cortex

CHIPS: an Extensible Toolbox for Cellular and Hemodynamic Two-Photon Image Analysis

Barrett MJP – Neuroinformatics

oxygen-porphyrin

Stabilizing g‑States in Centrosymmetric Tetrapyrroles: Two-Photon- Absorbing Porphyrins with Bright Phosphorescence

Esipova TV – Journal of Physical Chemistry

The relative influence of hematocrit and red blood cell velocity on oxygen transport from capillaries to tissue

Lücker A – Microcirculation

microvascular-network

Depth-dependent flow and pressure characteristics in cortical microvascular networks

Schmid F – PLoS Computational Biology

The SAFIR experiment: Concept, status and perspectives

Becker R – Nuclear Instruments and Methods in Physics Research A

Deviant Processing in the Primary Somatosensory Cortex

Musall S – Cerebral Cortex

oxygen-porphyrin

Two-Photon Absorbing Phosphorescent Metalloporphyrins: Effects of π‑Extension and Peripheral Substitution

Esipova TV – Journal of the American Chemical Society

lactate-gradient

In vivo evidence for a lactate gradient from astrocytes to neurons

Mächler P – Cell Metabolism

Design and performance of an ultra-flexible two-photon microscope for in vivo research

Mayrhofer JM – Biomedical Optics Express

A probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia

Castillo X – Journal of Cerebral Blood Flow & Metabolism

NH4(+) triggers the release of astrocytic lactate via mitochondrial pyruvate shunting

Lerchundi R – Proceedings of the National Academy of Sciences

Sparse, reliable, and long-term stable representation of periodic whisker deflections in the mouse barrel cortex

Mayrhofer JM – NeuroImage

A dynamic model of oxygen transport from capillaries to tissue with movingred blood cells

Lücker A – American Journal of Physiology-Heart and Circulatory Physiology

The impact of capillary dilation on the distribution of red blood cells in artificial networks

Schmid F – American Journal of Physiology - Heart and Circulatory Physiology

potassium-lactate

Channel-Mediated Lactate Release by K+-Stimulated Astrocytes

Sotelo-Hitschfeld T – Journal of Neuroscience

Tactile frequency discrimination is enhanced by circumventing neocortical adaptation

Musall S – Nature Neuroscience

Joint 3-D vessel segmentation and centerline extraction using oblique Hough forests with steerable filters

Schneider M – Medical Image Analysis

TGIF: Topological Gap In-Fill for Vascular Networks

Schneider M – Medical Image Computing and Computer-Assisted Intervention

Multimodal Imaging in Rats Reveals Impaired Neurovascular Coupling in Sustained Hypertension

Calcinaghi N – Stroke

Two-photon microscopy with double-circle trajectories for in vivo cerebral blood flow measurements

Landolt A – Experiments in Fluids

Somatotopic Astrocytic Activity in the Somatosensory Cortex

Ghosh A – Glia

Novel two-alternative forced choice paradigm for bilateral vibrotactile whisker frequency discrimination in head-fixed mice and rats

Mayrhofer JM – Journal of Neurophysiology

Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury

Spescha RD – European Heart Journal

Quantification of brain glucose metabolism by FDG PET with real time arterial and image derived input function in mice

Alf MF – Journal of Nuclear Medicine

Reorganization of cortical population activity imaged throughout long-term sensory deprivation

Margolis DJ – Nature Neuroscience

Tissue metabolism driven arterial tree generation

Schneider M – Medical Image Analysis

A two-compartment mathematical model of neuroglial metabolism using [1-11C] acetate

Lanz B – Journal of Cerebral Blood Flow and Metabolism

Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response

Calcinaghi N – Journal of Cerebral Blood Flow Metabolism

In vivo evidence for lactate as a neuronal energy source

Wyss MT – Journal of Neuroscience

Physiologically based construction of optimized 3-D arterial tree models.

Schneider M – Medical Image Computing and Computer-Assisted Intervention

microvasculature

The Microvascular System of the Striate and Extrastriate Visual Cortex of the Macaque

Weber B – Cerebral Cortex

Related news

3

New Cover in Stroke in Collaboration with Mohamad El Amki and Daniel Razansky

Dr. Mohamad El Amki

Jeanne Droux

Dr. Mohamad El Amki,Jeanne Droux, + 3 more

New Cover in Neuron in Collaboration with Mohamad El Amki and Susanne Wegener

Dr. Mohamad El Amki

Dr. Chaim Glück

Dr. Mohamad El Amki,Dr. Chaim Glück, + 3 more

The Lab Starts a New Swiss National Science Foundation Project on February 1: Nanoscale Structure of the Microvascular-astrocytic Interface

1 February 2024

Prof. Dr. Bruno Weber

Dr. Ladina Hösli

Prof. Dr. Bruno Weber,Dr. Ladina Hösli

More team members

Dr. Anita Siebert

Dr. Anita Siebert

Scientific Coordinator

Manuela Ouazzan

Manuela Ouazzan

Assistant to the Head of Institute

PD Dr. Dr. Matthias T Wyss

Senior Scientists

Dr. Tina Notter

Dr. Tina Notter

Senior Scientists