1 May 2024
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Dr. Mohamad El Amki,Dr. Chaim Glück, + 3 more
New Cover in Neuron in Collaboration with Mohamad El Amki and Susanne Wegener
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Dr. Mohamad El Amki,Dr. Chaim Glück, + 3 more
Group Leader
Prof. Dr. Bruno Weber
About
We ask very simple questions about the most complex system on the planet. Fascinated by these simple questions and how challenging it is to answer them, my goal is to bring together the very best people with the very best tools. Apart from running the lab for Neuroenergetics and Experimental Imaging, I act as the Director of the Institute of Pharmacology and Toxicology.
Related publications
Pia-FLOW: Deciphering hemodynamic maps of the pial vascular connectome and its response to arterial occlusion
Glueck C – PNAS
Astrocytes adopt a progenitor-like migratory strategy for regeneration in adult brain
Herwerth M, Wyss MT – bioRXiv
The Astrocyte: Metabolic Hub of the Brain
Barros LF – Cold Spring Harbor Perspectives in Biology
Leptomeningeal collaterals regulate reperfusion in ischemic stroke
Binder NF, El Amki M – Neuron
Oligodendrocyte–axon metabolic coupling is mediated by extracellular K+ and maintains axonal health
Looser ZJ – Nature Neuroscience
Sensitive multicolor indicators for monitoring norepinephrine in vivo
Kagiampaki Z – Nature Communications
Transcranial cortex-wide imaging of murine ischemic perfusion with large-field multifocal illumination fluorescence microscopy
Chen Z – Biorxiv
Deep optoacoustic localization microangiography of ischemic stroke in mice
Deán-Ben XL – Nature Communications
Ultrasound trapping and navigation of microrobots in the mouse brain vasculature
Del Campo Fonseca A – Nature Communications
SAFIR-I: first NEMA NU 4-2008-based performance characterization
Bebié P – European Journal of Nuclear Medicine and Molecular Imaging
Simultaneous dynamic glucose-enhanced (DGE) MRI and fiber photometry measurements of glucose in the healthy mouse brain
Eleftheriou A – NeuroImage
Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation
Todorova V – Molecular Neurodegeneration
Pericyte remodeling is deficient in the aged brain and contributes to impaired capillary flow and structure
Berthiaume AA – Nature Communications
A genetically encoded sensor for in vivo imaging of orexin neuropeptides
Duffet L – Nature Methods
Three-dimensional wide-field fluorescence microscopy for transcranial mapping of cortical microcirculation
Zhou Q – Nature Communications
Altered hemodynamics and vascular reactivity in a mouse model with severe pericyte deficiency
Stobart J – Journal of Cerebral Blood Flow and Metabolism
Measurement of cerebral oxygen pressure in living mice by two-photon phosphorescence lifetime microscopy
Erlebach E – STAR Protocols
Vascular Response to Spreading Depolarization Predicts Stroke Outcome
Binder NF – Stroke
Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning
Hoesli L – Cell Reports
Direct vascular contact is a hallmark of cerebral astrocytes
Hoesli L – Cell Reports
Fear learning induces α7-nicotinic acetylcholine receptor-mediated astrocytic responsiveness that is required for memory persistence
Zhang K – Nature Neuroscience
Diversity of neurovascular coupling dynamics along vascular arbors in layer II/III somatosensory cortex.
Rungta RL – Communications Biology
Distinct signatures of calcium activity in brain mural cells
Glueck C – eLife
The severity of microstrokes depends on local vascular topology and baseline perfusion
Schmid F – eLife
Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans
Passini FS – Nature Biomedical Engineering
DeepVesselNet: Vessel Segmentation, Centerline Prediction, and Bifurcation Detection in 3-D Angiographic Volumes
Tetteh G – Frontiers in Neuroscience
Predicting Vessel Diameter Changes to Up-Regulate Biphasic Blood Flow During Activation in Realistic Microvascular Networks
Epp R – Frontiers in Physiology
A complete pupillometry toolbox for real-time monitoring of locus coeruleus activity in rodents
Privitera M – Nature Protocols
A Bright and Colorful Future for G-Protein Coupled Receptor Sensors
Ravotto L – Frontiers in Cellular Neuroscience
Structural basis of astrocytic Ca2+ signals at tripartite synapses
Arizono M – Nature Communications
Arousal-induced cortical activity triggers lactate release from astrocytes
Zuend M – Nature Metabolism
Initial Characterization of the SAFIR Prototype PET-MR Scanner
Ritzer C – IEEE transactions on radiation and plasma medical sciences
Neutrophils Obstructing Brain Capillaries Are a Major Cause of No-Reflow in Ischemic Stroke
El Amki M, Glueck C – Cell Reports
Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation
Zerbi V – Neuron
In vivo imaging with a water immersion objective affects brain temperature, blood flow and oxygenation
Roche M – eLife
Red blood cells stabilize flow in brain microvascular networks
Schmid F – PLoS Computational Biology
Oxyphor 2P: A High-Performance Probe for Deep- Tissue Longitudinal Oxygen Imaging
Esipova TV – Cell Metabolism
Non-Canonical Control of Neuronal Energy Status by the Na+ Pump
Baeza-Lehnert F – Cell Metabolism
The Relation between Capillary Transit Times and Hemoglobin Saturation Heterogeneity. Part 2: Capillary Networks
Lücker A – Frontiers in Physiology
Cortical Circuit Activity Evokes Rapid Astrocyte Calcium Signals on a Similar Timescale to Neurons
Stobart J – Neuron
The Relation between Capillary Transit Times and Hemoglobin Saturation Heterogeneity. Part 1: Theoretical Models
Lücker A – Frontiers in Physiology
Intravitreal AAV-Delivery of Genetically Encoded Sensors Enabling Simultaneous Two-Photon Imaging and Electrophysiology of Optic Nerve Axons
Looser ZJ – Frontiers in Cellular Neuroscience
DCC Is Required for the Development of Nociceptive Topognosis in Mice and Humans
da Silva RV – Cell Reports
Long-term in vivo calcium imaging of astrocytes reveals distinct cellular compartment responses to sensory stimulation
Stobart J – Cerebral Cortex
CHIPS: an Extensible Toolbox for Cellular and Hemodynamic Two-Photon Image Analysis
Barrett MJP – Neuroinformatics
Stabilizing g‑States in Centrosymmetric Tetrapyrroles: Two-Photon- Absorbing Porphyrins with Bright Phosphorescence
Esipova TV – Journal of Physical Chemistry
The relative influence of hematocrit and red blood cell velocity on oxygen transport from capillaries to tissue
Lücker A – Microcirculation
Depth-dependent flow and pressure characteristics in cortical microvascular networks
Schmid F – PLoS Computational Biology
The SAFIR experiment: Concept, status and perspectives
Becker R – Nuclear Instruments and Methods in Physics Research A
Deviant Processing in the Primary Somatosensory Cortex
Musall S – Cerebral Cortex
Two-Photon Absorbing Phosphorescent Metalloporphyrins: Effects of π‑Extension and Peripheral Substitution
Esipova TV – Journal of the American Chemical Society
In vivo evidence for a lactate gradient from astrocytes to neurons
Mächler P – Cell Metabolism
Design and performance of an ultra-flexible two-photon microscope for in vivo research
Mayrhofer JM – Biomedical Optics Express
A probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia
Castillo X – Journal of Cerebral Blood Flow & Metabolism
NH4(+) triggers the release of astrocytic lactate via mitochondrial pyruvate shunting
Lerchundi R – Proceedings of the National Academy of Sciences
Sparse, reliable, and long-term stable representation of periodic whisker deflections in the mouse barrel cortex
Mayrhofer JM – NeuroImage
A dynamic model of oxygen transport from capillaries to tissue with movingred blood cells
Lücker A – American Journal of Physiology-Heart and Circulatory Physiology
The impact of capillary dilation on the distribution of red blood cells in artificial networks
Schmid F – American Journal of Physiology - Heart and Circulatory Physiology
Channel-Mediated Lactate Release by K+-Stimulated Astrocytes
Sotelo-Hitschfeld T – Journal of Neuroscience
Tactile frequency discrimination is enhanced by circumventing neocortical adaptation
Musall S – Nature Neuroscience
Joint 3-D vessel segmentation and centerline extraction using oblique Hough forests with steerable filters
Schneider M – Medical Image Analysis
TGIF: Topological Gap In-Fill for Vascular Networks
Schneider M – Medical Image Computing and Computer-Assisted Intervention
Multimodal Imaging in Rats Reveals Impaired Neurovascular Coupling in Sustained Hypertension
Calcinaghi N – Stroke
Two-photon microscopy with double-circle trajectories for in vivo cerebral blood flow measurements
Landolt A – Experiments in Fluids
Somatotopic Astrocytic Activity in the Somatosensory Cortex
Ghosh A – Glia
Novel two-alternative forced choice paradigm for bilateral vibrotactile whisker frequency discrimination in head-fixed mice and rats
Mayrhofer JM – Journal of Neurophysiology
Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury
Spescha RD – European Heart Journal
Quantification of brain glucose metabolism by FDG PET with real time arterial and image derived input function in mice
Alf MF – Journal of Nuclear Medicine
Reorganization of cortical population activity imaged throughout long-term sensory deprivation
Margolis DJ – Nature Neuroscience
Tissue metabolism driven arterial tree generation
Schneider M – Medical Image Analysis
A two-compartment mathematical model of neuroglial metabolism using [1-11C] acetate
Lanz B – Journal of Cerebral Blood Flow and Metabolism
Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response
Calcinaghi N – Journal of Cerebral Blood Flow Metabolism
In vivo evidence for lactate as a neuronal energy source
Wyss MT – Journal of Neuroscience
Physiologically based construction of optimized 3-D arterial tree models.
Schneider M – Medical Image Computing and Computer-Assisted Intervention
The Microvascular System of the Striate and Extrastriate Visual Cortex of the Macaque
Weber B – Cerebral Cortex
Related news
1 February 2024
Prof. Dr. Bruno Weber,Dr. Ladina Hösli
The Lab Starts a New Swiss National Science Foundation Project on February 1: Nanoscale Structure of the Microvascular-astrocytic Interface
Prof. Dr. Bruno Weber,Dr. Ladina Hösli