1 May 2024
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Dr. Mohamad El Amki,Dr. Chaim Glück, + 3 more
New Cover in Neuron in Collaboration with Mohamad El Amki and Susanne Wegener
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Dr. Mohamad El Amki,Dr. Chaim Glück, + 3 more
Senior Scientists
PD Dr. Dr. Matthias T Wyss
About
After completing my medical studies in 2001, I got during my MD project fascinated by the complexity of the brain and the various imaging methods visualizing it and stayed in science ever since. My research mainly focuses on the use of various imaging modalities ranging from 2P microscopy up to PET imaging to investigate how energy supply to the brain is organized at different levels and how it changes in pathologic situations. Research allows you to go on a new journey every day!
Related publications
Astrocytes adopt a progenitor-like migratory strategy for regeneration in adult brain
Herwerth M, Wyss MT – bioRXiv
Leptomeningeal collaterals regulate reperfusion in ischemic stroke
Binder NF, El Amki M – Neuron
Transcranial cortex-wide imaging of murine ischemic perfusion with large-field multifocal illumination fluorescence microscopy
Chen Z – Biorxiv
The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases
Wyss MT – Neural Regeneration Research
Simultaneous dynamic glucose-enhanced (DGE) MRI and fiber photometry measurements of glucose in the healthy mouse brain
Eleftheriou A – NeuroImage
Axon degeneration: new actor in an old play
Herwerth M, Wyss MT – Neural Regeneration Research
Measurement of cerebral oxygen pressure in living mice by two-photon phosphorescence lifetime microscopy
Erlebach E – STAR Protocols
Vascular Response to Spreading Depolarization Predicts Stroke Outcome
Binder NF – Stroke
P2R Inhibitors Prevent Antibody‑Mediated Complement Activation in an Animal Model of Neuromyelitis Optica
Kalluri SR – Neurotherapeutics
A complete pupillometry toolbox for real-time monitoring of locus coeruleus activity in rodents
Privitera M – Nature Protocols
Arousal-induced cortical activity triggers lactate release from astrocytes
Zuend M – Nature Metabolism
Initial Characterization of the SAFIR Prototype PET-MR Scanner
Ritzer C – IEEE transactions on radiation and plasma medical sciences
Neutrophils Obstructing Brain Capillaries Are a Major Cause of No-Reflow in Ischemic Stroke
El Amki M, Glueck C – Cell Reports
DCC Is Required for the Development of Nociceptive Topognosis in Mice and Humans
da Silva RV – Cell Reports
In vivo evidence for a lactate gradient from astrocytes to neurons
Mächler P – Cell Metabolism
Design and performance of an ultra-flexible two-photon microscope for in vivo research
Mayrhofer JM – Biomedical Optics Express
A probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia
Castillo X – Journal of Cerebral Blood Flow & Metabolism
NH4(+) triggers the release of astrocytic lactate via mitochondrial pyruvate shunting
Lerchundi R – Proceedings of the National Academy of Sciences
Channel-Mediated Lactate Release by K+-Stimulated Astrocytes
Sotelo-Hitschfeld T – Journal of Neuroscience
Multimodal Imaging in Rats Reveals Impaired Neurovascular Coupling in Sustained Hypertension
Calcinaghi N – Stroke
Two-photon microscopy with double-circle trajectories for in vivo cerebral blood flow measurements
Landolt A – Experiments in Fluids
Somatotopic Astrocytic Activity in the Somatosensory Cortex
Ghosh A – Glia
Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury
Spescha RD – European Heart Journal
Quantification of brain glucose metabolism by FDG PET with real time arterial and image derived input function in mice
Alf MF – Journal of Nuclear Medicine
A two-compartment mathematical model of neuroglial metabolism using [1-11C] acetate
Lanz B – Journal of Cerebral Blood Flow and Metabolism
Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response
Calcinaghi N – Journal of Cerebral Blood Flow Metabolism
In vivo evidence for lactate as a neuronal energy source
Wyss MT – Journal of Neuroscience